The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development

A novel mouse gap junction gene, coding for a presumptive protein of 258 amino acids (molecular mass: 28 981 Da), has been designated connexin29. This single copy gene was mapped to distal mouse chromosome 5 and shows 75% sequence identity to a human connexin30.2 sequence in the database. Connexin29...

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Bibliographic Details
Published in:	Biological chemistry Vol. 382; no. 6; p. 973
Main Authors:	Söhl, G, Eiberger, J, Jung, Y T, Kozak, C A, Willecke, K
Format:	Journal Article
Language:	English
Published:	Germany 01-06-2001
Subjects:	Age Factors Animals Base Sequence Brain - growth & development Brain Chemistry - genetics Chromosome Mapping Connexins - genetics Gap Junctions - genetics Gene Expression Regulation, Developmental Mice - genetics Molecular Sequence Data RNA, Messenger - metabolism Sciatic Nerve - metabolism Sequence Alignment
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Summary:	A novel mouse gap junction gene, coding for a presumptive protein of 258 amino acids (molecular mass: 28 981 Da), has been designated connexin29. This single copy gene was mapped to distal mouse chromosome 5 and shows 75% sequence identity to a human connexin30.2 sequence in the database. Connexin29 mRNA (4.4 kb) is highly expressed in mouse sciatic nerve and less abundant in spinal cord as well as in adult brain, where it increased 12-fold between day 7 and 14 post partum. Our expression data suggest that the new connexin gene is active in myelin-forming glial cells.
ISSN:	1431-6730
DOI:	10.1515/BC.2001.122