Multinuclear (Sn/Pd) complexes with disodium 2,2′-(dithiocarboxyazanediyl)diacetate hydrate; Synthesis, characterization and biological activities

• Published in: Journal of coordination chemistry Vol. 70; no. 24; pp. 4070 - 4092
• Main Authors: Hussain, Shabbir, Ali, Saqib, Shahzadi, Saira, Shahid, Muhammad, Tahir, Asif Ali, Mustansar Abbas, Syed, Riaz, Muhammad, Ahmad, Iqbal, Hussain, Imdad
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 17-12-2017; Taylor & Francis Ltd
• Subjects: Alkaline phosphatase; Antiinfectives and antibacterials; antimicrobial; Antimicrobial agents; Bacteria; Bimetals; Chelation; Deoxyribonucleic acid; Derivatives; DNA; Fungicides; hemolytic; Iridium; NMR; Nuclear magnetic resonance; Palladium; Salmon; Sn(IV)/Pd(II); Solid state; SS-DNA; Substitution reactions; Thermal degradation; Tin
• ISSN: 0095-8972; 1029-0389
• DOI: 10.1080/00958972.2017.1411908

Bimetallic chlorodi-/triorganotin(IV) derivatives of general formulas R
2
(H
2
O)SnLCSSSn(Cl)R
2
(R=Me: 1; Ph: 2) and R
3
Sn(Na)LCSSSnR
3
·H
2
O (R=Bu: 3; Ph: 4) were prepared by reaction of iminodiacetic acid disodium salt hydrate (Na
2
LH) with CS
2
and R
2
SnCl
2
/R
3
SnCl in methanol. The reaction between Na
2
LH, CS
2
, and PdCl
2
produced [Na
2
LCSS]
2
Pd·2H
2
O (5) which was treated with R
3
SnCl to synthesize the heterobimetallic derivatives [R
3
Sn(Na)LCSS]
2
Pd·2H
2
O (R=Me: 6; Ph: 7). The complexes were characterized by microanalysis, spectroscopic, and thermogravimetric analyses. Elemental analysis data, mass fragmentation, and thermal degradation patterns supported the molecular composition of the complexes. FT-IR data indicated monodentate binding of carboxylate while a chelating coordination mode of the dithiocarboxylate was verified in the solid state. A five-coordinate tin(IV) was demonstrated in the solid state. In solution, a tetrahedral/trigonal bipyramidal configuration around Sn(IV) and a square planar geometry of Pd(II) was indicated by multinuclear NMR (
1
H and
13
C) and UV-visible studies. The Pd(II) derivatives showed interaction with salmon sperm-DNA and caused an inhibition of alkaline phosphatase (ALPs). The antibacterial/antifungal potential of the coordination products varied with the nature of incorporated metal and a substitution pattern at tin(IV); the palladium metallation decreased the antimicrobial activities. The triorganotin(IV) products exhibited more powerful action against bacteria/fungi as compared to their diorganotin(IV) counterparts. The complexes displayed sufficiently lower hemolytic effects in vitro as compared to triton X-100 and slightly higher than PBS.