Sudden death in growth hormone–treated children with Prader-Willi syndrome

A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 144; no. 1; pp. 129 - 131
Main Authors:	Vliet, Guy Van, Deal, Cheri L., Crock, Patricia A., Robitaille, Yves, Oligny, Luc L.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-01-2004 Elsevier
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bronchopneumonia - chemically induced Child, Preschool Contraindications Death, Sudden - etiology Emergency and intensive care: neonates and children. Prematurity. Sudden death Fatal Outcome General aspects Human Growth Hormone - adverse effects Human Growth Hormone - therapeutic use Humans Intensive care medicine Male Medical sciences Metabolic diseases Obesity Prader-Willi Syndrome - drug therapy GH PWS Endocrinopathy Human Pediatrics Sudden death Diseases of the osteoarticular system Somatotropin hormone Genetic disease Case study Treatment Adenohypophyseal hormone Complex syndrome Child Prader Labhart Willi syndrome
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Summary:	A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2003.09.049