Rab11a Regulates the Development of Cilia and Establishment of Planar Cell Polarity in Mammalian Vestibular Hair Cells

Vestibular organs have unique planar cell polarity ( Figure 1A ), and their normal development and function are dependent on the regular polarity of cilia ( Figure 1B ) requires. Rab11a is a small G protein that participates in the transportation of intracellular and extracellular materials required...

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Bibliographic Details
Published in:	Frontiers in molecular neuroscience Vol. 14; p. 762916
Main Authors:	Chen, Bin-Jun, Qian, Xiao-qing, Yang, Xiao-yu, Jiang, Tao, Wang, Yan-mei, Lyu, Ji-han, Chi, Fang-lu, Chen, Ping, Ren, Dong-dong
Format:	Journal Article
Language:	English
Published:	Lausanne Frontiers Research Foundation 19-11-2021 Frontiers Media S.A
Subjects:	Cell division Cilia development Ethanol Hair Hair cells Laboratory animals Mammals Morphology Neuroscience planar cell polarity Polarity Proteins Rab11a Utricle vestibular Vestibular system United States > US Japan
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Summary:	Vestibular organs have unique planar cell polarity ( Figure 1A ), and their normal development and function are dependent on the regular polarity of cilia ( Figure 1B ) requires. Rab11a is a small G protein that participates in the transportation of intracellular and extracellular materials required for polarity formation; however, our understanding of the mechanisms of the actions of Rab11a in vestibular organs is limited. Here, we showed that the general shape of the utricle was abnormal in Rab11a CKO/CKO mice. These mice also showed abnormal morphology of the stereocilia bundles, which were reduced in both length and number, as well as disturbed tissue-level polarity. Rab11a affected the distribution of polarity proteins in the vestibular organs, indicating that the normal development of cilia requires Rab11a and intraflagellar transportation. Furthermore, small G protein migration works together with intraflagellar transportation in the normal development of cilia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Takahisa Furukawa, Osaka University, Japan; Kazusaku Kamiya, Juntendo University, Japan This article was submitted to Molecular Signaling and Pathways, a section of the journal Frontiers in Molecular Neuroscience These authors have contributed equally to this work Edited by: Hiroshi Hibino, Osaka University, Japan
ISSN:	1662-5099 1662-5099
DOI:	10.3389/fnmol.2021.762916