Nodular basal cell carcinoma in Gorlin's syndrome treated with systemic photodynamic therapy and interstitial optical fiber diffuser laser

• Published in: Journal of the American Academy of Dermatology Vol. 55; no. 5; pp. S86 - S89
• Main Authors: Madan, Vishal, Loncaster, Juliette A., Allan, Donald, Lear, John T., Sheridan, Linda, Leach, Catherine, Allan, Ernest
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01-11-2006; Elsevier
• Subjects: Adult; Basal Cell Nevus Syndrome - drug therapy; Biological and medical sciences; Carcinoma, Basal Cell - drug therapy; Dermatology; Dihematoporphyrin Ether - therapeutic use; Diseases of the skin. Cosmetics; Humans; Laser Therapy; Male; Medical sciences; Middle Aged; Optics and Photonics; Photochemotherapy; Photosensitizing Agents - therapeutic use; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Skin Neoplasms - drug therapy; Tumors of the skin and soft tissue. Premalignant lesions; NBCC; PDT; BCC; ALA; Skin disease; Basal cell carcinoma; Photodynamic therapy; Treatment; Dermatology; Laser; Systemic route; Malignant tumor; Basal cell nevus syndrome; Genetic disease; Optical fiber
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2005.12.004

Nodular basal cell carcinomas resistant to multiple forms of treatment in two patients with nevoid basal cell carcinoma syndrome (Gorlin's syndrome) were treated with systemic porfimer sodium–based photodynamic therapy. Interstitially placed optical diffuser fibers were used to deliver light. Good response to treatment was seen on clinical evaluation and on measurement by a 20-MHz high-resolution ultrasound.