Oxygen Affinity and Electrolyte Distribution of Human Blood: Changes Induced by Propranolol

Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs-Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 182; no. 4109; pp. 300 - 301
Main Authors:	Agostoni, A., Berfasconi, C., Gerli, G. C., Luzzana, M., Rossi-Bernardi, L.
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 19-10-1973
Subjects:	Blood Blood plasma Cell membranes Diphosphoglyceric Acids - blood Electrolytes Erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Hemoglobins Humans Hydrogen-Ion Concentration Oxygen Oxygen - blood Potassium Potassium - blood Propranolol - pharmacology Sodium Sodium - blood
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Summary:	Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs-Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3-diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.182.4109.300