Adoptive T-cell therapy for cancer in the United kingdom: a review of activity for the British Society of Gene and Cell Therapy annual meeting 2015

• Published in: Human gene therapy Vol. 26; no. 5; p. 276
• Main Authors: Gilham, David Edward, Anderson, John, Bridgeman, John Stephen, Hawkins, Robert Edward, Exley, Mark Adrian, Stauss, Hans, Maher, John, Pule, Martin, Sewell, Andrew Kelvin, Bendle, Gavin, Lee, Steven, Qasim, Waseem, Thrasher, Adrian, Morris, Emma
• Format: Journal Article
• Language: English
• Published: United States 01-05-2015
• Subjects: Animals; Biotechnology; Cell- and Tissue-Based Therapy; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Immunotherapy, Adoptive - methods; Neoplasms - immunology; Neoplasms - therapy; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; United Kingdom
• ISSN: 1557-7422
• DOI: 10.1089/hum.2015.024

Adoptive T-cell therapy is delivering objective clinical responses across a number of cancer indications in the early phase clinical setting. Much of this clinical activity is taking place at major clinical academic centers across the United States. This review focuses upon cancer-focused cell therapy activity within the United Kingdom as a contribution to the 2015 British Society of Gene and Cell Therapy annual general meeting. This overview reflects the diversity and expansion of clinical and preclinical studies within the United Kingdom while considering the background context of this work against new infrastructural developments and the requirements of nationalized healthcare delivery within the UK National Health Service.