Oxygen delivery and consumption in patients with hyperdynamic septic shock

• Published in: Critical care medicine Vol. 15; no. 1; p. 26
• Main Authors: Astiz, M E, Rackow, E C, Falk, J L, Kaufman, B S, Weil, M H
• Format: Journal Article
• Language: English
• Published: United States 01-01-1987
• Subjects: Aged; Aged, 80 and over; Female; Fluid Therapy; Hemodynamics; Humans; Lactates - blood; Lactic Acid; Male; Middle Aged; Oxygen - blood; Oxygen Consumption; Shock, Septic - blood; Shock, Septic - metabolism; Shock, Septic - physiopathology
• ISSN: 0090-3493
• DOI: 10.1097/00003246-198701000-00005

We analyzed the relationship of increases in oxygen delivery to changes in oxygen consumption in ten patients with hyperdynamic septic shock. Increases in oxygen delivery from 413 +/- 14 (SEM) to 535 +/- 19 ml/min X m2 (p less than .01) were associated with increases in oxygen consumption from 136 +/- 10 to 161 +/- 5 ml/min X m2 (p less than .05). Arterial lactate decreased from 4.6 +/- 1.6 to 2.1 +/- 0.3 mmol/L (p less than .05). These observations suggest that oxygen utilization is perfusion-limited in hyperdynamic septic shock.