Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis

• Published in: Russian journal of general chemistry Vol. 91; no. 7; pp. 1282 - 1291
• Main Authors: Bogdanov, A. V., Andreeva, O. V., Belenok, M. G., Voloshina, A. D., Enikeeva, K. I., Samorodov, A. V., Mironov, V. F.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-07-2021; Springer; Springer Nature B.V
• Subjects: Acetylsalicylic acid; Anticoagulants (Medicine); Aspirin; Carbohydrates; Chemical reactions; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Hydrazones; Sugar; hemotoxicity; click reactions; antimicrobial activity; isatin; hydrazones; glycoconjugates
• ISSN: 1070-3632; 1608-3350
• DOI: 10.1134/S1070363221070045

The click reaction of propargylisatins with some azido-sugars was used to synthesize new isatin derivatives, in which the carbohydrate residue is linked to the 2,3-dioxindole scaffold via the 1,2,3-triazole ring. A number of water-soluble acylhydrazones with various structure of cationic fragment were obtained on their basis. It was shown that the newly obtained compounds do not exhibit hemotoxic action and have a significant antiaggregatory and anticoagulant activity at the level of reference drugs such as acetylsalicylic acid and pentoxifylline.