Criteria for the prenatal diagnosis of holoprosencephaly

Holoprosencephaly is a congenital anomaly of the central nervous system whose prenatal sonographic appearance may to similar to that of ventriculomegaly. A clear differential diagnosis is extremely important because the two conditions have different prognoses and therefore require different obstetri...

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Bibliographic Details
Published in:	American journal of perinatology Vol. 4; no. 1; p. 41
Main Authors:	Pilu, G, Romero, R, Rizzo, N, Jeanty, P, Bovicelli, L, Hobbins, J C
Format:	Journal Article
Language:	English
Published:	United States 01-01-1987
Subjects:	Brain - abnormalities Cerebral Ventricles - abnormalities Diagnosis, Differential Face - abnormalities Female Humans Pregnancy Pregnancy Trimester, Second Prenatal Diagnosis Prognosis Ultrasonography
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Summary:	Holoprosencephaly is a congenital anomaly of the central nervous system whose prenatal sonographic appearance may to similar to that of ventriculomegaly. A clear differential diagnosis is extremely important because the two conditions have different prognoses and therefore require different obstetric management. Eight cases of prenatally recognized holoprosencephaly are analyzed and criteria for a specific diagnosis proposed. The specificity and limitations of ultrasound findings, such as identification of a holoventricle, presence of a dorsal sac, and facial anomalies are discussed.
ISSN:	0735-1631
DOI:	10.1055/s-2007-999735