Is there a relationship between serum S-100β protein and neuropsychologic dysfunction after cardiopulmonary bypass?

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 119; no. 1; pp. 132 - 137
• Main Authors: Westaby, Stephen, Saatvedt, Kjell, White, Samantha, Katsumata, Takahiro, van Oeveren, Willem, Bhatnagar, Narendra K., Brown, Stuart, Halligan, Peter W.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01-01-2000; Elsevier
• Subjects: Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Medical sciences; Thoracic and cardiovascular surgery. Cardiopulmonary bypass; Cardiopulmonary bypass; Human; Nervous system diseases; S 100 Protein; Dysfunction; Biological marker; Anesthesia; Complication; Neurological disorder; Neuropsychologia
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/S0022-5223(00)70228-5

Objectives: Over the past decade, the glial protein S-100β has been used to detect cerebral injury in a number of clinical settings including cardiac surgery. Previous investigations suggest that S-100β is capable of identifying patients with cerebral dysfunction after cardiopulmonary bypass. Whether detection of elevated levels S-100β reflects long-term cognitive impairment remains to be shown. The present study evaluated whether perioperative release of S-100β after coronary artery operations with cardiopulmonary bypass could predict early or late neuropsychologic impairment. Methods: A total of 100 patients undergoing elective coronary bypass without a previous history of neurologic events were prospectively studied. To exclude noncerebral sources of S-100β, we did not use cardiotomy suction or retransfusion of shed mediastinal blood. Serial perioperative measurements of S-100β were performed with the use of a new sensitive immunoluminometric assay up to 8 hours after the operation. Patients underwent cognitive testing on a battery of 11 tests before the operation, before discharge from the hospital, and 3 months later. Results: No significant correlation was found between S-100β release and neuropsychologic measures either 5 days or 3 months after the operation. Conclusion: Despite using a sensitive immunoluminometric assay of S-100β, we found no evidence to support the suggestion that early release of S-100β may reflect long-term neurologic injury capable of producing cognitive impairment. (J Thorac Cardiovasc Surg 2000;119:132-7)