Epigenomics of clear cell renal cell carcinoma： mechanisms and potential use in molecular pathology

• Published in: Chinese journal of cancer research Vol. 28; no. 1; pp. 80 - 91
• Main Authors: Xing, Tianying, He, Huiying
• Format: Journal Article
• Language: English
• Published: China Department of Urology, Peking University Third Hospital, Beijing 100191, China%Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China 01-02-2016; Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; AME Publishing Company
• Subjects: microRNA; Review; 分子病理学; 机制; 潜在用途; 癌; 细胞; 肾; 表观遗传学; DNA methylation; long noncoding RNA; microRNA; histone modification; clear cell renal cell carcinoma (ccRCC)
• ISSN: 1000-9604; 1993-0631
• DOI: 10.3978/j.issn.1000-9604.2016.02.09

Clear cell renal cell carcinoma （ccRCC） is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high- throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.