Independent predictors of survival in endometrium cancer: platelet-to-lymphocyte ratio and platelet/neutrophil/monocyte-to-lymphocyte ratio

• Published in: Journal of the Turkish German Gynecological Association Vol. 19; no. 2; pp. 78 - 86
• Main Authors: Kimyon Cömert, Günsu, Türkmen, Osman, Kar, İrem, Sınacı, Selcan, Yılmaz Ergani, Seval, Karalök, Alper, Başaran, Derman, Turan, Taner
• Format: Journal Article
• Language: English
• Published: Istanbul Turkish-German Gynecological Association 04-06-2018; Galenos Publishing House; Galenos Publishing
• Subjects: Endometrial cancer; Lymphocytes; Original Investigation; Ovarian cancer; Systematic review; Tıp; İstanbul; platelet; monocyte; Endometrium cancer; neutrophil; lymphocyte
• ISSN: 1309-0399; 1309-0380
• DOI: 10.4274/jtgga.2017.0112

Objective: To evaluate the association between ratios of inflammatory markers and survival in endometrium cancer (EC).
Material and Methods: Four hundred ninety-seven patients with epithelial EC were included. The evaluated ratios were neutrophil (N)/lymphocyte (L), neutrophil count divided by the lymphocyte count; platelet (P)/lymphocyte, platelets divided by the lymphocyte count; lymphocyte/monocyte (M), lymphocytes divided by the monocyte count; NM/L, neutrophil plus monocyte divided by the lymphocyte count; PNM/L, the sum total counts of platelets, neutrophils and monocytes divided by the lymphocyte count.
Results: The median follow-up time was 24 months (1-129). Recurrence and exitus occurred in 34 (7%) and 18 (3.7%) patients, respectively. Metastasis in pelvic or para-aortic lymph nodes were significantly related only with low L/M. None of the inflammatory ratios were associated with disease-free survival. In multi-variant analysis, only high P/L (>168) and high PNM/L (>171) were related with a statistically significant hazard ratio for death of 2.91 (p=0.024) and 2.93 (p=0.023), respectively.
Conclusion: The P/L and PNM/L were in relation with worse overall survival and also independent prognostic factors for OS. (J Turk Ger Gynecol Assoc 2018; 19: 78-86)