Immunological dissection of human Ia molecules

The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by s...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 148; no. 6; pp. 1592 - 1611
Main Authors:	Tosi, R, Tanigaki, N, Centis, D, Ferrara, G B, Pressman, D
Format:	Journal Article
Language:	English
Published:	United States The Rockefeller University Press 01-12-1978
Subjects:	Antigen-Antibody Reactions Antigens, Surface - analysis Antigens, Surface - genetics B-Lymphocytes - immunology Cell Line Complement Activation Cytotoxicity, Immunologic Epitopes HLA Antigens - genetics Humans Isoantigens - analysis Macromolecular Substances Major Histocompatibility Complex
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.148.6.1592