Mitochondrial disease in adults: a scale to monitor progression and treatment

The natural history of mitochondrial diseases is poorly understood, limiting our ability to offer prognostic advice to patients or to evaluate therapy. One major obstacle to improving our understanding is the lack of a clinical rating scale to monitor the extensive clinical spectrum of mitochondrial...

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Bibliographic Details
Published in:	Neurology Vol. 66; no. 12; pp. 1932 - 1934
Main Authors:	Schaefer, A M, Phoenix, C, Elson, J L, McFarland, R, Chinnery, P F, Turnbull, D M
Format:	Journal Article
Language:	English
Published:	United States 27-06-2006
Subjects:	Disease Progression Female Health Status Indicators Humans Male Middle Aged Mitochondrial Diseases - diagnosis Mitochondrial Diseases - therapy Outcome Assessment, Health Care - methods Prognosis Quality of Life Reproducibility of Results Sensitivity and Specificity Surveys and Questionnaires Treatment Outcome
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Summary:	The natural history of mitochondrial diseases is poorly understood, limiting our ability to offer prognostic advice to patients or to evaluate therapy. One major obstacle to improving our understanding is the lack of a clinical rating scale to monitor the extensive clinical spectrum of mitochondrial disease. In this article, the authors describe the development and validation of a practical and semiquantitative rating scale, the Newcastle Mitochondrial Disease Adult Scale.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000219759.72195.41