Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia

• Published in: JCI insight Vol. 7; no. 4
• Main Authors: Salavatian, Siamak, Hoang, Jonathan D, Yamaguchi, Naoko, Lokhandwala, Zulfiqar Ali, Swid, Mohammed Amer, Armour, John Andrew, Ardell, Jeffrey L, Vaseghi, Marmar
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22-02-2022; American Society for Clinical investigation
• Subjects: Animals; Cardiology; Disease Models, Animal; Female; Heart - innervation; Heart Rate - physiology; Male; Myocardial Infarction - physiopathology; Neurons - metabolism; Neuroscience; Nociception - physiology; Nodose Ganglion - physiopathology; Swine; Synaptic Transmission - physiology; Vagus Nerve - physiopathology; Cardiology; Cardiovascular disease; Neuroscience
• ISSN: 2379-3708; 2379-3708
• DOI: 10.1172/jci.insight.155747

Myocardial infarction causes pathological changes in the autonomic nervous system, which exacerbate heart failure and predispose to fatal ventricular arrhythmias and sudden death. These changes are characterized by sympathetic activation and parasympathetic dysfunction (reduced vagal tone). Reasons for the central vagal withdrawal and, specifically, whether myocardial infarction causes changes in cardiac vagal afferent neurotransmission that then affect efferent tone, remain unknown. The objective of this study was to evaluate whether myocardial infarction causes changes in vagal neuronal afferent signaling. Using in vivo neural recordings from the inferior vagal (nodose) ganglia and immunohistochemical analyses, structural and functional alterations in vagal sensory neurons were characterized in a chronic porcine infarct model and compared with normal animals. Myocardial infarction caused an increase in the number of nociceptive neurons but a paradoxical decrease in functional nociceptive signaling. No changes in mechanosensitive neurons were observed. Notably, nociceptive neurons demonstrated an increase in GABAergic expression. Given that nociceptive signaling through the vagal ganglia increases efferent vagal tone, the results of this study suggest that a decrease in functional nociception, possibly due to an increase in expression of inhibitory neurotransmitters, may contribute to vagal withdrawal after myocardial infarction.