Role of Granulocyte Colony-Stimulating Factor in the Management of Infection with Fusarium oxysporum in a Neutropenic Child

• Published in: Clinical infectious diseases Vol. 18; no. 3; p. 490
• Main Authors: Hennequm, C., Benkerrou, M., Gaillard, J. L., Blanche, S., Fraitag, S.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-03-1994; University of Chicago Press
• Subjects: Amphotericin B - administration & dosage; Biological and medical sciences; Colony stimulating factors; Correspondence; Dosage; Drug Therapy, Combination; Female; Fungal infections; Fusariosis; Fusarium; Fusarium oxysporum; Granulocyte Colony-Stimulating Factor - administration & dosage; Granulocytes; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infant; Infections; Lesions; Medical sciences; Mycoses - complications; Mycoses - drug therapy; Neutropenia - complications; Neutrophils; Opportunistic behavior; Human; Fusarium oxysporum; Leukopenia; Mycosis; Hemopathy; Fungi; Infection; Case study; Chemotherapy; Granulocyte colony stimulating factor; Treatment; Fungi Imperfecti; Disseminated; Child; Thallophyta; Neutropenia
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/clinids/18.3.490

We read with interest the report by Spielberger et al. about the successful treatment of disseminated fusariosis with the combination of amphotericin B (AmB), granulocyte transfusions, and granulocyte-macrophage colony-stimulating factor (GM-CSF). We have recently used high doses of AmB combined with granulocyte colony-stimulating factor (G-CSF) as adjuvant therapy to successfully treat disseminated cutaneous fusariosis in a neutropenic child.