Arene Ruthenium Metalla-Assemblies with Anthracene Moieties for PDT Applications

• Published in: Inorganics Vol. 6; no. 3; p. 97
• Main Authors: Gaschard, Marie, Nehzat, Farzaneh, Cheminel, Thomas, Therrien, Bruno
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-09-2018
• Subjects: Acetone; Anthracene; arene ruthenium; Assemblies; Cancer therapies; Chemistry; Crystal structure; Hypoxia; Light; Light irradiation; metalla-assemblies; Molecular structure; NMR; Nuclear magnetic resonance; p-Cymene; photodynamic therapy; Rectangles; Ruthenium; Single crystals; singlet oxygen; Structural analysis; Tumors; White light
• ISSN: 2304-6740; 2304-6740
• DOI: 10.3390/inorganics6030097

The synthesis and characterization of three metalla-rectangles of the general formula [Ru4(η6-p-cymene)4(μ4-clip)2(μ2-Lanthr)2][CF3SO3]4 (Lanthr: 9,10-bis(3,3’-ethynylpyridyl) anthracene; clip = oxa: oxalato; dobq: 2,5-dioxido-1,4-benzoquinonato; donq: 5,8-dioxido-1,4-naphthoquinonato) are presented. The molecular structure of the metalla-rectangle [Ru4(η6-p-cymene)4(μ4-oxa)2(μ2-Lanthr)2]4+ has been confirmed by the single-crystal X-ray structure analysis of [Ru4(η6-p-cymene)4(μ4-oxa)2(μ2-Lanthr)2][CF3SO3]4 · 4 acetone (A2 · 4 acetone), thus showing the anthracene moieties to be available for reaction with oxygen. While the formation of the endoperoxide form of Lanthr was observed in solution upon white light irradiation, the same reaction does not occur when Lanthr is part of the metalla-assemblies.