Comparative study between thulium laser and cold knife visual urethrotomy for treatment of short bulbomembranous urethral stricture

• Published in: Medicine (Baltimore) Vol. 101; no. 35; p. e30235
• Main Authors: Rehan, Mohamed, Elnady, Esam A., Khater, Saed, Elsayed, Ahmed Fawzi Arafat, Abdel Gawad, Ahmed M., Freeg, Mohamed Abdel Hafeez Aly, Mahmoud, Alaa R.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 02-09-2022
• Subjects: Clinical Trial/Experimental Study
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000030235

Introduction: The classical way to treat urethral stricture is the direct vision cold knife internal urethrotomy (DVIU). Along with advances in laser technology, laser urethrotomy is widely used, such as neodymium-doped yttrium aluminum garnet, argon, potassium titanyl phosphate, and thulium laser. We aimed to compare thulium laser urethrotomy (TLU) and cold knife visual urethrotomy (CKVU) in terms of short bulbomembranous urethral stricture management. Materials and methods: This prospective interventional study was conducted for 24 months, from January 2018 to January 2020, on 60 patients with primary short bulbo-membranous urethral stricture who came to the Department of Urology of Al-Azhar University Hospital, New Damietta, Egypt. We divided these patients into 2 age-matched groups; 30 patients treated with CKVU and 30 patients with TLU. Results: Regarding efficacy, postvoid residual urine volume (PVR) was reduced significantly in both groups ( P < .001) after 6 months of follow-up; however, the reduction in TLU was greater than CKVU ( P = .008). The improvement of Qmax after 6 months was significant and comparable in both groups. Regarding the quality of life, both groups showed a significant (<0.05) improvement in international prostate symptom score (IPSS) and the Male Sexual Health Questionnaire (MSHQ) scale, without no significant difference between both groups (>0.05). TLU showed a significantly ( P = .038) shorter operative duration (24 ± 4.17 min) than CKVU duration (33 ± 4.86 min). Compared with CKVU, TLU was associated with less blood loss during surgery ( P = .001), lower recurrence rate (46.7% vs. 19.97%, respectively), and lower frequencies of urethral dilatation ( P = .001). Conclusion: TLU is an effective and safe therapy for managing bulbomembranous urethral strictures, with a relatively low recurrence rate. Further investigations of other techniques are recommended to look for the most appropriate procedure to combat the urethral stricture problem.