Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy- N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 14; no. 4; pp. 1078 - 1088
Main Authors:	Bouissane, L., El Kazzouli, S., Léonce, S., Pfeiffer, B., Rakib, E.M., Khouili, M., Guillaumet, G.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-02-2006
Subjects:	Animals Cell Cycle - drug effects Cell Line, Tumor Humans Indazole Indazoles - chemical synthesis Indazoles - chemistry Indazoles - pharmacology L1210 murine leukemia cells Leukemia - pathology Mice Molecular Structure Palladium Structure-Activity Relationship Sulfonamide Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Palladium Sulfonamide Indazole L1210 murine leukemia cells
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Summary:	We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy- N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC 50 of 0.44 μM.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2005.09.037