Case Report: Amphotericin B and Mefloquine as a Salvage Treatment of Alveolar Echinococcosis

Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therap...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 108; no. 3; pp. 581 - 583
Main Authors:	Jelicic, Karlo, Papic, Neven, Viskovic, Klaudija, Vince, Adriana
Format:	Journal Article
Language:	English
Published:	United States Institute of Tropical Medicine 01-03-2023 The American Society of Tropical Medicine and Hygiene
Subjects:	Albendazole - therapeutic use Amphotericin B - therapeutic use Animals Anthelmintics - therapeutic use Case Report Case reports Echinococcosis - drug therapy Echinococcus multilocularis Humans Male Medical treatment Mefloquine - therapeutic use Parasites Parasitic diseases Salvage Therapy Zoonoses
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Summary:	Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therapy, there are no alternatives. Here, we present a patient with advanced alveolar echinococcosis who was successfully treated with amphotericin B deoxycholate and mefloquine as a rescue therapy after he developed albendazole intolerance.
Bibliography:	Authors’ Addresses: Karlo Jelicic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, E-mail: kjelicic@bfm.hr. Neven Papic and Adriana Vince, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and School of Medicine, University of Zagreb, Zagreb, Croatia, E-mails: npapic@bfm.hr and avince@bfm.hr. Klaudija Viskovic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and Faculty of Health Studies, University of Rijeka, Rijeka, Croatia, E-mail: kviskovic@bfm.hr.
ISSN:	0002-9637 1476-1645
DOI:	10.4269/ajtmh.22-0465