Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice

• Published in: Food and chemical toxicology Vol. 141; p. 111403
• Main Authors: Lambert, Karen, Gondeau, Claire, Briolotti, Philippe, Scheuermann, Valérie, Daujat-Chavanieu, Martine, Aimond, Franck
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-07-2020; Elsevier
• Subjects: Animals; Basal Metabolism; Biocompatible Materials; Biocompatible modified water; Biomarkers - metabolism; Diet, High-Fat; Drinking Water; Endocrinology and metabolism; Food and Nutrition; Hepatic steatosis; High fat high sucrose diet; Human health and pathology; Insulin Resistance; Life Sciences; Lipogenesis; Liver Glycogen - metabolism; Male; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - metabolism; Metabolic Syndrome - prevention & control; Mice; Mice, Inbred C57BL; Obesity - complications; Obesity - etiology; Tap water; Insulin resistance; High fat high sucrose diet; Hepatic steatosis; Metabolic syndrome; Tap water; Biocompatible modified water
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2020.111403

The prevalence of metabolic syndrome (MetS), elevating cardiovascular risks, is increasing worldwide, with no available global therapeutic options. The intake of plain, mineral or biocompatible modified waters was shown to prevent some MetS features. This study was designed to analyze, in mice fed a high fat and sucrose diet (HFSD), the effects on MetS features of the daily intake of a reverse osmosed, weakly remineralized, water (OW) and of an OW dynamized by a physical processing (ODW), compared to tap water (TW). The HFSD was effective at inducing major features of MetS such as obesity, hepatic steatosis and inflammation, blood dyslipidemia, systemic glucose intolerance and muscle insulin resistance. Compared to TW, OW intake decreased hepatic fibrosis and inflammation, and mitigated hepatic steatosis and dyslipidemia. ODW intake further improved skeletal muscle insulin sensitivity and systemic glucose tolerance. This study highlights the deleterious metabolic impacts of the daily intake of TW, in combination with a high energy diet, and its possible involvement in MetS prevalence increase. In addition, it demonstrates that biocompatible modified water may be promising non-pharmaceutical, cost-effective tools for nutritional approaches in the treatment of MetS.
•High energy diet and tap water intake induce metabolic syndrome features in mice.•Reverse osmosed water intake prevents hepatic steatosis and serum dyslipidemia.•Reverse osmosed water intake decreases hepatic fibrosis and inflammation.•Dynamization of reverse osmosed water further improves muscle insulin sensitivity.•Biocompatible modified water may be tools to prevent metabolic syndrome features.