Pharmacogenetics in the Treatment of Cardiovascular Diseases and Its Current Progress Regarding Implementation in the Clinical Routine

• Published in: Genes Vol. 10; no. 4; p. 261
• Main Authors: Dávila-Fajardo, Cristina Lucía, Díaz-Villamarín, Xando, Antúnez-Rodríguez, Alba, Fernández-Gómez, Ana Estefanía, García-Navas, Paloma, Martínez-González, Luis Javier, Dávila-Fajardo, José Augusto, Barrera, José Cabeza
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-04-2019; MDPI
• Subjects: Acenocoumarol - adverse effects; Acenocoumarol - therapeutic use; Acute coronary syndromes; Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Antiviral agents; Aryl Hydrocarbon Hydroxylases - genetics; Blood platelets; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Clinical medicine; Clinical trials; Clopidogrel; Clopidogrel - adverse effects; Clopidogrel - therapeutic use; Cytochrome P-450 CYP2C9 - genetics; Drug dosages; Drug stores; Guidelines as Topic; Humans; Pharmacogenetics; Polymorphism; Precision Medicine; Review; Simvastatin; Simvastatin - adverse effects; Simvastatin - therapeutic use; Stroke; Warfarin - adverse effects; Warfarin - therapeutic use; clopidogrel; acenocoumarol; pharmacogenetics; warfarin
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes10040261

There is a special interest in the implementation of pharmacogenetics in clinical practice, although there are some barriers that are preventing this integration. A large part of these pharmacogenetic tests are focused on drugs used in oncology and psychiatry fields and for antiviral drugs. However, the scientific evidence is also high for other drugs used in other medical areas, for example, in cardiology. In this article, we discuss the evidence and guidelines currently available on pharmacogenetics for clopidogrel, warfarin, acenocoumarol, and simvastatin and its implementation in daily clinical practice.