The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials

• Published in: Archives of pharmacal research Vol. 46; no. 5; pp. 389 - 407
• Main Authors: Liu, Jianhong, Zhang, Ming, Deng, Dan, Zhu, Xiao
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01-05-2023; 대한약학회
• Subjects: Aging; Diabetes Mellitus, Type 2 - drug therapy; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Medicine; Metformin - pharmacology; Metformin - therapeutic use; Neoplasms - drug therapy; Pharmacology/Toxicology; Pharmacy; Review; 약학; Hypoglycemic; Repairing the brain; Metformin; Anti-aging; Cancer
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-023-01445-2

Metformin has been used clinically for more than 60 years. As time goes by, more and more miraculous effects of metformin beyond the clinic have been discovered and discussed. In addition to the clinically approved hypoglycemic effect, it also has a positive metabolic regulation effect on the human body that cannot be ignored. Such as anti-cancer, anti-aging, brain repair, cardiovascular protection, gastrointestinal regulation, hair growth and inhibition of thyroid nodules, and other nonclinical effects. Metformin affects almost the entire body in the situation taking it over a long period, and the preventive effects of metformin in addition to treating diabetes are also beginning to be recommended in some guidelines. This review is mainly composed of four parts: the development history of metformin, the progress of clinical efficacy, the nonclinical efficacy of metformin, and the consideration and prospect of its application.