Review of Experimental Carcinogenesis by Compounds Related to Vinyl Chloride

• Published in: Environmental health perspectives Vol. 41; pp. 211 - 220
• Main Authors: Chu, Kenneth C., Milman, Harry A.
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01-10-1981
• Subjects: Aerosols; Animals; Bioassay; Chlorides; Conference to Reevaluate the Toxicity of Vinyl Chloride Monomer, Poly(vinyl Chloride) and Structural Analogs. National Institutes of Health, Bethesda, MD. March 20-21, 1980; Corn oil; Cricetinae; Cricetulus; Dichloroethylenes - toxicity; Dosage; Enteral Nutrition; Female; Gavage; Hydrocarbons, Halogenated - toxicity; Inhalation; Liver; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental - chemically induced; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tetrachloroethylene - toxicity; Trichloroethylene - toxicity; Tumors; Vinyl Chloride - analogs & derivatives; Vinyl Chloride - toxicity; Vinyl Compounds - toxicity
• ISSN: 0091-6765; 1552-9924
• DOI: 10.1289/ehp.8141211

The experimental carcinogenesis results on six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, and dichloroethane was carcinogenic in Osborne-Mendel rats and B6C3F1 mice. Dibromoethane, given by gavage and inhalation, was carcinogenic in B6C3F1 mice, F344 rats and Osborne-Mendel rats. Finally, epichlorohydrin was carcinogenic in male Sprague-Dawley rats and B6C3F1 mice.