Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease

• Published in: Journal of clinical medicine Vol. 12; no. 21; p. 6753
• Main Authors: Nordén, Kristine Røren, Dagfinrud, Hanne, Semb, Anne Grete, Hisdal, Jonny, Metsios, George S, Sexton, Joseph, Fongen, Camilla, Bakke, Emilie Andrea, Tveter, Anne Therese
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-11-2023
• Subjects: Algorithms; Arthritis; Blood pressure; Body mass index; Calibration; Cardiopulmonary system; Cardiovascular disease; Cardiovascular diseases; Cardiovascular system; Care and treatment; Clinical medicine; Complications and side effects; Evaluation; Exercise; Fitness equipment; Health aspects; Heart rate; Interval training; Mortality; Patients; Physical fitness; Psoriatic arthritis; Pulmonary function tests; Respiratory organs; Rheumatoid arthritis; Risk factors; Validity; Norway; United States > US; Germany
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12216753

Cardiorespiratory fitness (CRF) is an excellent marker of overall health. This study aimed to assess criterion validity and responsiveness of estimated CRF models (eCRF) in patients with inflammatory joint disease (IJD). CRF was measured directly as peak oxygen uptake (VO2peak) by a Cardiopulmonary Exercise Test (CPET), while one generic eCRF model (eCRFGEN) and two disease-specific eCRF models (eCRFALT and eCRFPGA) were used to estimate CRF at baseline and after 3 months in 55 Norwegian patients with IJD. Moderate correlations were observed between eCRFGEN, eCRFALT, eCRFPGA, and VO2peak at baseline (ICC 0.60, 0.64 and 0.62, respectively) and 3 months (ICC 0.62, 0.65 and 0.57, respectively). All eCRF models overestimated measured VO2peak, and there was large variability in agreement of individual measurements at baseline and at 3 months. Weak correlations were observed for responsiveness of eCRFGEN (ICC 0.39), eCRFALT (ICC 0.40) and eCRFPGA (ICC 0.39). Mean differences between change in eCRF models and change in VO2peak were small, but the wide limits of agreement exceeded the pre-defined clinically acceptable margins. The eCRF models possessed adequate ability to detect ≥3.5 mL/kg/min improvement in VO2peak. eCRF may suffice for group-level assessment, but caution is advised when applying eCRF to individual patients with IJD.