Recent advances in electrochemical non-enzymatic glucose sensors – A review

• Published in: Analytica chimica acta Vol. 1033; pp. 1 - 34
• Main Authors: Hwang, Dae-Woong, Lee, Saram, Seo, Minjee, Chung, Taek Dong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 29-11-2018; Elsevier BV
• Subjects: Adatoms; Alloy plating; Biosensing Techniques; Chemical sensors; Commercialization; Electrochemical sensor; Electrochemical Techniques; Electrochemistry; Extracellular Fluid - chemistry; Glucose; Glucose - analysis; Glucose oxidation; Glucose sensor; Gold; Laboratory tests; Metals; Nanomaterial; Nanomaterials; Nanoporous; Non-enzymatic; Organic materials; Oxidation; Oxides; Platinum; Sensors; Transition metal alloys; Transition metals; Non-enzymatic; Glucose sensor; Electrochemical sensor; Nanomaterial; Nanoporous; Glucose oxidation
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2018.05.051

This review encompasses the mechanisms of electrochemical glucose detection and recent advances in non-enzymatic glucose sensors based on a variety of materials ranging from platinum, gold, metal alloys/adatom, non-precious transition metal/metal oxides to glucose-specific organic materials. It shows that the discovery of new materials based on unique nanostructures have not only provided the detailed insight into non-enzymatic glucose oxidation, but also demonstrated the possibility of direct detection in whole blood or interstitial fluids. We critically evaluate various aspects of non-enzymatic electrochemical glucose sensors in terms of significance as well as performance. Beyond laboratory tests, the prospect of commercialization of non-enzymatic glucose sensors is discussed.
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•This review summarizes the latest progress in non-enzymatic electrochemical sensors.•The review encompasses fundamental principles of electrochemical glucose detection.•The merits and demerits of various electrode materials are discussed.•The authors critically evaluate numerous aspects concerning current research.•The prospect of clinical application of non-enzymatic glucose monitoring is described.