Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 64; no. 2; pp. 398 - 399
• Main Authors: Estis, Joel, Wu, Alan H B, Todd, John, Bishop, Jeff, Sandlund, Johanna, Kavsak, Peter A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-02-2018
• Subjects: Age; Age Factors; Aged; Alanine; Alkaline phosphatase; Biomarkers; Calcium-binding protein; Carbon dioxide; Creatinine; Extreme values; Female; Heart attacks; Heart diseases; Hemoglobin; Humans; Laboratories; Limit of Detection; Male; Men; Mens health; Middle Aged; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Patients; Population; Reference Values; Retrospective Studies; Sex Factors; Skewed distributions; Thyroid; Troponin; Troponin I; Troponin I - blood; Troponin I - standards; Tumor necrosis factor-TNF; Women; Canada; United States > US; San Francisco California
• ISSN: 0009-9147; 1530-8561
• DOI: 10.1373/clinchem.2017.276972

N-terminal pro-brain natriuretic peptide (normal: <125 or <450pg/mLfor <75 and >75 years, respectively), tumor necrosis factor a (normal: <3.0 pg/ mL, cutoff set at the 95th percentile from 279 self-reported healthy donors), thyroid-stimulating hormone (normal: 0.27-4.20 ^.IU/mL), hemoglobin A1c (normal: <5.6%), alanine aminotransferase (normal: 5-33 or 5-41 U/L for women and men, respectively), total bilirubin (normal: <1.3 mg/dL), alkaline phosphatase (normal: 35-104 or 40-129 U/L for women and men, respectively), calcium (normal: 8.610.2 mg/dL), creatinine (estimated glomerular filtration rate not available, normal: 0.5-0.9 or 0.7-1.2 mg/dL for women and men, respectively), sodium (normal: 136-145 mmol/L), potassium (normal: 3.55.1 mmol/L), and carbon dioxide (normal: 22-29 mmol/L). After defining the apparently healthy population, outliers were considered using the Tukey method, but this method was too restrictive because of the highly right-skewed cTnI distribution. [...]the Vanderloo Extreme Values and Reed outlier methods were separately applied to the cTnI results. [...]universal definition of myocardial infarction.