Nrf-2 as a therapeutic target in acute kidney injury

• Published in: Life sciences (1973) Vol. 264; p. 118581
• Main Authors: Hejazian, Seyyedeh Mina, Hosseiniyan Khatibi, Seyed Mahdi, Barzegari, Abolfazl, Pavon-Djavid, Graciela, Razi Soofiyani, Saiedeh, Hassannejhad, Sina, Ahmadian, Elham, Ardalan, Mohammadreza, Zununi Vahed, Sepideh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-01-2021; Elsevier BV
• Subjects: Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; AKI; Animals; Antioxidants; Antioxidants - administration & dosage; Detoxification; Drug Delivery Systems - methods; Drug Delivery Systems - trends; GA-binding protein; Gene expression; Homeostasis; Humans; Inflammation; Injuries; Keap1-Nrf-2 system; Kidney diseases; Kidneys; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial dysfunction; Molecular modelling; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Renal injury; Signal Transduction - drug effects; Signal Transduction - physiology; Therapeutic targets; Renal injury; Oxidative stress; Mitochondrial dysfunction; AKI; Keap1-Nrf-2 system
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2020.118581

Multifaceted cellular pathways exhibit a crucial role in the preservation of homeostasis at the molecular, cellular, and organism levels. One of the most important of these protective cascades is Nuclear factor E2-related factor (Nrf-2) that regulates the expression of several genes responsible for cellular detoxification, antioxidant function, anti-inflammation, drug/xenobiotic transportation, and stress-related factors. A growing body of evidence provides information regarding the protective role of Nrf-2 against a number of kidney diseases. Acute kidney injury (AKI) is a substantial clinical problem that causes a huge social burden. In the kidneys, Nrf-2 exerts a dynamic role in improving the injury triggered by inflammation and oxidative stress. Understanding of the exact molecular mechanisms underlying AKI is vital in order to determine the equilibrium between renal adaptation and malfunction and thus reduce disease progression. This review highlights the role of Nrf-2 targeting against AKI and provides evidence that targeting Nrf-2 to prevail oxidative damage and its consequences might exhibit protective effects in kidney diseases.