Clinical and ultrasonography follow-up of five cases of calcinosis cutis successfully treated with intralesional sodium thiosulfate

• Published in: Journal of ultrasound Vol. 25; no. 4; pp. 995 - 1003
• Main Authors: Tubau, Carla, Cubiró, Xavier, Amat-Samaranch, Victoria, Garcia-Melendo, Cristina, Puig, Lluís, Roé-Crespo, Esther
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-12-2022; Springer Nature B.V
• Subjects: Medicine; Medicine & Public Health; Nodules; Pictorial; Pictorial Essay; Sodium thiosulfate; Thiosulfates; Ultrasound; Treatment; Calcinosis cutis; Ultrasound imaging; Intralesional sodium thiosulfate; Echography; Follow-up
• ISSN: 1876-7931; 1971-3495; 1876-7931
• DOI: 10.1007/s40477-022-00665-4

Calcinosis cutis (CC) is characterized by deposit of calcium salts in the skin and subcutaneous tissue; its clinical presentation consists of indurated painful nodules, which can ulcerate and become superinfected. CC treatment remains a challenge, yet successful treatment with intralesional (IL) sodium thiosulfate (STS) has been reported in several CC subtypes. Herein we are reporting on a case series of 5 patients with CC successfully treated with IL-STS. We describe the 18–22 MHz ultrasound characteristics of the lesions and on follow-up after treatment. Ultrasound imaging was useful in guiding IL-STS injections and confirming response to treatment.