AmyloGraph: a comprehensive database of amyloid-amyloid interactions

• Published in: Nucleic acids research Vol. 51; no. D1; pp. D352 - D357
• Main Authors: Burdukiewicz, Michał, Rafacz, Dominik, Barbach, Agnieszka, Hubicka, Katarzyna, Bąkała, Laura, Lassota, Anna, Stecko, Jakub, Szymańska, Natalia, Wojciechowski, Jakub W, Kozakiewicz, Dominika, Szulc, Natalia, Chilimoniuk, Jarosław, Jęśkowiak, Izabela, Gąsior-Głogowska, Marlena, Kotulska, Małgorzata
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 06-01-2023
• Subjects: Amyloid; Amyloidogenic Proteins - metabolism; Database Issue; Databases, Protein; Peptides
• ISSN: 0305-1048; 1362-4962
• DOI: 10.1093/nar/gkac882

Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 experimentally studied interactions between 46 amyloid proteins or peptides. We also proposed a novel standardized terminology for the description of amyloid-amyloid interactions, which is included in our database, covering all currently known types of such a cross-talk, including inhibition of fibrillization, cross-seeding and other phenomena. The new approach allows for more specific studies on amyloids and their interactions, by providing very well-defined data. AmyloGraph, an online database presenting information on amyloid-amyloid interactions, is available at (http://AmyloGraph.com/). Its functionalities are also accessible as the R package (https://github.com/KotulskaLab/AmyloGraph). AmyloGraph is the only publicly available repository for experimentally determined amyloid-amyloid interactions.