New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging

Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remaine...

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Bibliographic Details
Published in:	Biochemical Society transactions Vol. 49; no. 3; p. 1299
Main Authors:	Li, Jieru, Pertsinidis, Alexandros
Format:	Journal Article
Language:	English
Published:	England 30-06-2021
Subjects:	Animals Binding Sites - genetics Enhancer Elements, Genetic - genetics Gene Expression Regulation Humans Promoter Regions, Genetic - genetics Protein Binding Single Molecule Imaging - methods Transcription Factors - metabolism Transcription, Genetic optical nanoscopy single-molecule approaches enhancers transcription genome organization
Online Access:	Get more information
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Summary:	Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remained a mystery. Here, we review the latest developments and insights into promoter-enhancer communication mechanisms revealed by live-cell, real-time single-molecule imaging approaches.
ISSN:	1470-8752
DOI:	10.1042/BST20200963