Antibiotic Scars Left on the Gut Microbiota from the Stringent Response

Antibiotic Scars Left on the Gut Microbiota from the Stringent Response

Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteri...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) Vol. 26; no. 9; pp. 735 - 737
Main Authors: Yi, Hyojeong, Kim, Heenam Stanley
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-09-2018
Elsevier Science Ltd
Subjects:
(p)ppGpp
Anti-Bacterial Agents - adverse effects
antibiotic persistence
antibiotic tolerance
Antibiotics
Bacteria - drug effects
Cicatrix - chemically induced
Cicatrix - microbiology
Drug Tolerance
Gastrointestinal Microbiome - drug effects
Gastrointestinal Tract - microbiology
Guanosine Pentaphosphate
gut microbiota
Humans
Impact damage
Intestinal microflora
Microbiota
Scars
Side effects
Stringent response
antibiotic tolerance
(p)ppGpp
antibiotic persistence
gut microbiota
stringent response
Online Access:Get full text
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Description
Summary:Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2018.06.003