The response of the neuronal activity in the somatosensory cortex after high-intensity intermediate-frequency magnetic field exposure to the spinal cord in rats under anesthesia and waking states

• Published in: Brain research Vol. 1747; p. 147063
• Main Authors: Saito, Atsushi, Wada, Keiji, Suzuki, Yukihisa, Nakasono, Satoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-11-2020
• Subjects: Gaussian-shaped burst; Intermediate-frequency magnetic field; Motor evoked potential; Rat; Somatosensory cortex; Spinal cord; Somatosensory cortex; SCS; Gaussian-shaped burst; Spinal cord; Intermediate-frequency magnetic field; Rat; MEP; WPT; Motor evoked potential; IF-MF; IH; SEP
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2020.147063

•High-intensity burst-type IF-MF exposure platform for rat was developed.•Stimulus responses were detected in cortex after IF-MF exposure to spinal cord.•The stimulus threshold was lower in the waking state than that of anesthesia.•The platform may contribute the safety assessment related with IF-MF exposure.
Novel technologies using the intermediate-frequency magnetic field (IF-MF) in living environments are becoming popular with the advance in electricity utilization. However, the biological effects induced by the high-intensity and burst-type IF-MF exposure used in the wireless power transfer technologies for electric vehicles or medical devices, such as the magnetic stimulation techniques, are not well understood. Here, we developed an experimental platform using rats, that combined an 18 kHz, high-intensity (Max. 88 mT), Gaussian-shaped burst IF-MF exposure system with an in vivo extracellular recording system. In this paper, we aimed to report the qualitative differences in stimulus responses in the regions of the somatosensory cortex and peripheral nerve fibers that were induced by the IF-MF exposure to the rat spinal cord. We also report the modulation of the stimulus responses in the somatosensory cortex under anesthesia or waking states. Using this experimental platform, we succeeded in the detection of the motor evoked potentials or the neuronal activity in the somatosensory cortex that was induced by the IF-MF exposure to the spinal cord in rats. Compared to the state of anesthesia, the neuronal activities in the somatosensory cortex was enhanced during the waking state. On the other hand, these neuronal responses could not be confirmed by the IF-MF exposure-related coil sound only. Our experimental results indicated the basic knowledge of the biological responses and excitation mechanisms of the spinal cord stimulation by the IF-MF exposure.