Dementia with features of Alzheimer's disease and HIV-associated dementia in an elderly man with AIDS

• Published in: AIDS (London) Vol. 23; no. 8; pp. 1029 - 1031
• Main Authors: BROUSSEAU, Kristin M, FILLEY, Christopher M, KAYE, Kathryn, KISER, Jennifer J, ADLER, Lawrence E, CONNICK, Elizabeth
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 15-05-2009
• Subjects: Acquired Immunodeficiency Syndrome - complications; Adult and adolescent clinical studies; AIDS Dementia Complex - complications; AIDS Dementia Complex - diagnosis; Alzheimer Disease - complications; Alzheimer Disease - diagnosis; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia - complications; Dementia - diagnosis; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neurology; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Positron-Emission Tomography; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Nervous system diseases; Alzheimer disease; Retroviridae; Male; AIDS; Immune deficiency; Lentivirus; Cerebral disorder; Infection; Virus; Viral disease; Central nervous system disease; Degenerative disease; Human immunodeficiency virus; Elderly
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/QAD.0b013e32832ac380

Improved survival of HIV-infected individuals increasingly poses new clinical challenges as they develop diseases associated with aging, such as dementia. Common risk factors (e.g. older age, lower education level, and apoli-poprotein e4 allele) and pathophysiology including chronic immune activation have been implicated in Alzheimer's disease and HIV-associated dementia. Although highly-active antiretroviral therapy has led to a decrease in HIV-associated dementia, it has been hypothesized that Alzheimer's disease will become epidemic among elderly HIV-infected individuals. Alzheimer's disease in a HIV-infected individual has not been described previously.