Impact of Immunity in Autism Spectrum Disorders

• Published in: European journal of inflammation Vol. 11; no. 1; pp. 23 - 31
• Main Authors: Tetè, S., Varvara, G., Murmura, G., Saggini, A., Maccauro, G., Rosati, M., Cianchetti, E., Tripodi, D., Toniato, E., Fulcheri, M., Caraffa, A., Antinolfi, P., Pandolfi, F., Potalivo, G., Conti, P., Theoharides, T.C.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-01-2013; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Autism; Cytokines; autism spectrum disorders; cytokines; immunity; inflammation
• ISSN: 2058-7392; 1721-727X; 2058-7392
• DOI: 10.1177/1721727X1301100103

Autism spectrum disorders (ASDs) are childhood psychopathologies characterized by having difficulties in social interaction, verbal and non-verbal communication as well as sensor motor movements. Evidence suggests that in ASDs environmental toxicant exposure, genetic and mitochondrial dysfunction are involved associated with abnormal immune response with allergic problems and elevated serum IgE. ASDs present the major cytokine and chemokine dysfunction in CNS and is mediated by an increase of pro-inflammatory cytokine levels in the brain, such as TNF, IL-1, IFN-γ, IL-6, IL-8 and others. Mast cells, which are also implicated in ASDs, are worsened by stress and produce proinflammatory cytokines and can be stimulated by neurotensin in the brain and gut, contributing also to the inflammatory response. However, the exact etiology of ASDs remains largely unknown.