Preoperative geniohyoid muscle mass in esophageal cancer patients is associated with swallowing function after esophagectomy

• Published in: Annals of gastroenterological surgery Vol. 8; no. 6; pp. 1026 - 1035
• Main Authors: Kawata, Sanshiro, Hiramatsu, Yoshihiro, Honke, Junko, Murakami, Tomohiro, Booka, Eisuke, Matsumoto, Tomohiro, Morita, Yoshifumi, Kikuchi, Hirotoshi, Yamauchi, Katsuya, Takeuchi, Hiroya
• Format: Journal Article
• Language: English
• Published: Tokyo John Wiley & Sons, Inc 01-11-2024; John Wiley and Sons Inc; Wiley
• Subjects: Body composition; Cancer therapies; Dissection; Dysphagia; Esophageal cancer; esophagectomy; Females; geniohyoid muscle; Larynx; Lymphatic system; Males; Musculoskeletal system; Original; Patients; Perioperative care; Pneumonia; recurrent laryngeal nerve palsy; Sarcopenia; Squamous cell carcinoma; Surgery; Surgical anastomosis; Swallowing; swallowing function; Tumors; Japan
• ISSN: 2475-0328; 2475-0328
• DOI: 10.1002/ags3.12839

Aim
Dysphagia often develops after esophagectomy. The geniohyoid muscle is involved in swallowing movements, but its significance in esophagectomy patients remains unclear. We investigated the relationship of preoperative geniohyoid muscle mass with post‐esophagectomy swallowing function.
Methods
We retrospectively analyzed 114 patients who underwent esophagectomy and gastric conduit reconstruction for esophageal malignancy. We evaluated preoperative geniohyoid muscle sagittal cross‐sectional areas (cm2) using computed tomography. Median values for each sex were considered as cutoff values. Dysphagia severity was assessed using the Penetration–Aspiration Scale (PAS) during video‐fluoroscopic swallowing studies performed 7–10 days postoperatively.
Results
The cross‐sectional area was significantly larger in males than in females (3.2 ± 0.7 vs. 2.4 ± 0.5, p < 0.01: median in males: 3.2 cm2, and in females: 2.3 cm2). These values were used to define high and low cross‐sectional area groups. The cross‐sectional area correlated positively with grip strength (correlation coefficient (CC) = 0.530) and skeletal muscle index (CC = 0.541). Transthyretin levels (22.4 ± 6.8 vs. 25.4 ± 5.5, p = 0.03) and cross‐sectional area (2.6 ± 0.7 vs. 3.2 ± 0.8, p < 0.01) were significantly lower in patients with (PAS score ≥6; 20%) than in those without aspiration during fluoroscopic swallowing studies. Recurrent laryngeal nerve palsy was significantly more frequent in those with than in those without aspiration during fluoroscopic studies (22% vs. 5%, p = 0.03). In the multivariate analysis, low cross‐sectional area and recurrent laryngeal nerve palsy were both independent risk factors for aspiration during swallowing studies (odds ratio = 3.6, p = 0.03 and odds ratio = 6.6, p = 0.02, respectively).
Conclusion
Preoperative geniohyoid muscle mass, evaluated using neck computed tomography, can predict dysphagia after esophagectomy.
The geniohyoid muscle mass before esophagectomy was correlated with a decrease in whole body muscle mass. It was associated with postoperative swallowing dysfunction.