Muscle volume loss as a prognostic marker in hepatocellular carcinoma patients treated with sorafenib

• Published in: Hepatology research Vol. 47; no. 6; pp. 558 - 565
• Main Authors: Hiraoka, Atsushi, Hirooka, Masashi, Koizumi, Yohei, Izumoto, Hirofumi, Ueki, Hidetaro, Kaneto, Miho, Kitahata, Shogo, Aibiki, Toshihiko, Tomida, Hideomi, Miyamoto, Yuji, Yamago, Hiroka, Suga, Yoshifumi, Iwasaki, Ryuichiro, Mori, Kenichiro, Miyata, Hideki, Tsubouchi, Eiji, Kishida, Masato, Ninomiya, Tomoyuki, Abe, Masanori, Matsuura, Bunzo, Kawasaki, Hideki, Hiasa, Yoichi, Michitaka, Kojiro
• Format: Journal Article
• Language: English
• Published: Netherlands Wiley Subscription Services, Inc 01-05-2017
• Subjects: Atrophy; Body mass; Body mass index; Classification; Computed tomography; Etiology; Hepatocellular carcinoma; Liver cancer; Medical prognosis; Metastases; muscle wasting; pre‐sarcopenia; prognosis; Prothrombin; Psoas muscle; sorafenib; Spine; Survival; Vertebrae; pre-sarcopenia; sorafenib; prognosis; hepatocellular carcinoma; muscle wasting
• ISSN: 1386-6346; 1872-034X
• DOI: 10.1111/hepr.12780

Aim
To elucidate the clinical significance of muscle wasting in regard to survival of hepatocellular carcinoma (HCC) patients undergoing sorafenib treatment, we evaluated prognostic factors including muscle wasting at the start of sorafenib treatment.
Methods
We enrolled 93 patients with unresectable HCC (68.3 ± 9.4 years old, 81 men, 12 women, Child–Pugh score 5:6:7 = 69:22:2) who were treated with sorafenib. Muscle wasting was evaluated based on psoas muscle area index (psoas muscle area at level of middle of third lumbar vertebra [cm2] / height [m]2) calculated from computed tomography findings. Previously reported cut‐off values for muscle wasting in men and women (4.24 and 2.50 cm2/m2, respectively) were used. Patients were divided into those with (muscle‐atrophy group, n = 20) and without (non‐atrophy group, n = 73) muscle wasting.
Results
There were no significant differences in regard to etiology, Child–Pugh classification, and tumor–node–metastasis stage between the groups. In contrast, body mass index in the muscle‐atrophy group was lower (20.9 ± 2.4 vs. 23.5 ± 3.4, P = 0.003). Although time to progression was not different (median 2.1 vs. 2.8 months, P = 0.242), the 6‐, 12‐, and 18‐month survival rates were worse in the muscle‐atrophy group (62.7%, 32.3%, and 32.3% vs. 78.3%, 64.7% and 48.1%, respectively, P = 0.042). In multivariate Cox hazard analysis, des‐γ‐carboxy prothrombin level (≥100 mAU/mL) (hazard ratio, 2.540; P = 0.018) and positive for muscle wasting (hazard ratio, 2.158; P = 0.032) were significant prognostic factors at the start of sorafenib treatment.
Conclusion
Muscle wasting is an important prognostic factor in patients treated with sorafenib.