Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom

• Published in: The veterinary journal (1997) Vol. 197; no. 2; pp. 496 - 498
• Main Authors: Warland, James, Dobson, Jane
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2013
• Subjects: Animals; Breed; Bull Terrier; carcinogenesis; Cavalier King Charles Spaniel; Cocker Spaniel; Dog; Dog Diseases - epidemiology; Dog Diseases - genetics; Dogs; English Springer Spaniel; Genetic Predisposition to Disease; German Shepherd; Golden Retriever; Incidence; Mast cell tumour; Mastocytoma - epidemiology; Mastocytoma - genetics; Mastocytoma - veterinary; neoplasms; Odds Ratio; terriers; United Kingdom - epidemiology; United Kingdom; Breed; Dog; Mast cell tumour; Incidence
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2013.02.017

Genetic factors play a major role in carcinogenesis. Many breeds have been reported to be predisposed to mast cell tumour (MCT) development using various methods and diverse control populations. A database of 222 dogs with MCT seen at a UK university referral hospital was compared to three control populations, namely, an insured population of UK dogs, registrations with the UK Kennel Club and other dogs seen through the same hospital. Odds ratios were calculated for each breed. Boxers, Labradors, Golden Retrievers and Staffordshire Bull Terriers appeared predisposed to MCT development. English Springer Spaniels, English Cocker Spaniels, German Shepherd Dogs, West Highland White Terriers and Cavalier King Charles Spaniels were underrepresented.