Simulation of Mechanical and Thermal Wounds of Soft Tissues

• Published in: Bulletin of experimental biology and medicine Vol. 173; no. 3; pp. 287 - 292
• Main Authors: Andreev, A. A., Glukhov, A. A., Ostroushko, A. P., Boev, S. N., Laptieva, A. Yu, Grigor’eva, E. V., Konovalov, P. A., Arkhipov, D. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2022; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell Biology; Development and progression; Infection; Infections; Inflammation; Injuries; Internal Medicine; Laboratory Medicine; Medical research; Medicine; Pathology; Reviews; Sepsis; Soft tissues; Trauma; Wound healing; Wounds; Wounds and injuries; soft tissues wounds; wound healing; purulent, aseptic, mechanical, and thermal wounds; modeling of wounds
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05535-x

Millions of accidental and surgical injuries of soft tissues are registered annually around the world [5]. Untimely and insufficiently effective treatment of wounds in 50-70% leads to the development of purulent-septic infection and the development of septic conditions and fatal outcomes [1-4], which necessitates thorough study of inflammatory and regenerative processes occurring in the injured soft tissues. Various models of mechanical and thermal damage to soft tissues are proposed for studying the inflammatory and reparative processes, for assessing the therapeutic effects and developing new approaches to wound treatment. However, the developed models do not fully meet the requirements of researchers and are not always simple and uniformly reproducible, close to the course of the pathology in humans, and highly reliable. When choosing the model of mechanical and thermal wounds, the experience of other researchers should be taken into consideration due to the need of actualization and improvement of existing models.