Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae

• Published in: International journal of molecular sciences Vol. 25; no. 4; p. 2134
• Main Authors: Luna-Pineda, Victor M, Rodríguez-Martínez, Griselda, Salazar-García, Marcela, Romo-Castillo, Mariana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10-02-2024
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; antibiotic resistance; Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; Biofilms; Cell cycle; Cloning; Drug resistance; Drug Resistance, Microbial; essential oils; Hospitals; Humans; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - genetics; Metabolites; Nosocomial infections; Pathogens; plant extracts; plant-origin compounds; Pneumonia; Public health; Severe acute respiratory syndrome coronavirus 2; Urinary tract diseases; Urinary tract infections; Urogenital system; Virulence; virulence factors; Virulence Factors - genetics; Italy; antibiotic resistance; plant extracts; treatment design; essential oils; plant-origin compounds; Klebsiella pneumoniae; virulence factors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25042134

(Kpn) is an opportunistic pathogen that causes intrahospital complications such as pneumonia, liver abscesses, soft tissue infections, urinary infections, bacteraemia, and, in some cases, death. Since this bacterium has a higher frequency than other Gram-negative pathogens, it has become an important pathogen to the health sector. The adaptative genome of Kpn likely facilitates increased survival of the pathogen in diverse situations. Therefore, several studies have been focused on developing new molecules, synergistic formulations, and biomaterials that make it possible to combat and control infections with and dispersion of this pathogen. Note that the uncontrolled antibiotic administration that occurred during the pandemic led to the emergence of new multidrug-resistant strains, and scientists were challenged to overcome them. This review aims to compile the latest information on Kpn that generates intrahospital infections, specifically their pathogenicity-associated factors. Furthermore, it explains the natural-product-based treatments (extracts and essential oils) developed for Kpn infection and dispersion control.