PROTAC cell permeability and oral bioavailability: a journey into uncharted territory

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Bibliographic Details
Published in:	Future medicinal chemistry Vol. 14; no. 3; pp. 123 - 126
Main Authors:	Poongavanam, Vasanthanathan, Kihlberg, Jan
Format:	Journal Article
Language:	English
Published:	England Newlands Press Ltd 2022
Subjects:	ADME ADME/Tox Administration, Oral assays Biological Availability Cell Membrane - drug effects drug design Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacokinetics Humans in vitro assays Ligands molecular chameleon Molecular Structure oral druggable space Permeability - drug effects Proteolysis - drug effects Tox Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - metabolism in vitro assays molecular chameleon oral druggable space ADME/Tox drug design
Online Access:	Get full text
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Description
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1
ISSN:	1756-8919 1756-8927 1756-8927
DOI:	10.4155/fmc-2021-0208