Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida

A new pentacyclic triterpenoid, 3alpha-(3",4"-dihydroxy- trans-cinnamoyloxy)- D-friedoolean-14-en-28-oic acid ( 1) has been isolated along with two known compounds, rhamnocitrin ( 2) and isorhamnetin ( 3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent a...

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Bibliographic Details
Published in:	Planta medica Vol. 70; no. 1; p. 65
Main Authors:	Sultanova, Nurgul, Makhmoor, Talat, Yasin, Amsha, Abilov, Z A, Omurkamzinova, V B, Atta-ur-Rahman, Choudhary, M Iqbal
Format:	Journal Article
Language:	English
Published:	Germany 01-01-2004
Subjects:	Antioxidants - chemistry Antioxidants - pharmacology Biphenyl Compounds Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Inhibitory Concentration 50 Phytotherapy Picrates - chemistry Plant Components, Aerial Serine Endopeptidases - drug effects Tamaricaceae Triterpenes - chemistry Triterpenes - pharmacology
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Summary:	A new pentacyclic triterpenoid, 3alpha-(3",4"-dihydroxy- trans-cinnamoyloxy)- D-friedoolean-14-en-28-oic acid ( 1) has been isolated along with two known compounds, rhamnocitrin ( 2) and isorhamnetin ( 3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP).
ISSN:	0032-0943
DOI:	10.1055/s-2004-815458