Effects of hydroxyurea and benzo(a)pyrene on DNA synthesis in the isolated perfused rat lung

The authors have investigated the feasibility of utilizing a perfused rat lung model to: (1) determine whether DNA synthesis can be measured ex vivo by ( super(3)H)-thymidine incorporation, (2) determine the response of DNA synthesis to hydroxyurea with the eventual aim of characterizing chemically-...

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Bibliographic Details
Published in:	Bulletin of environmental contamination and toxicology Vol. 28; no. 2; pp. 135 - 140
Main Authors:	Imamura, T, Busby, Jr, W F, Goldman, M E, Wogan, G N, Brunengraber, H
Format:	Journal Article
Language:	English
Published:	United States 01-02-1982
Subjects:	Animals Benzo(a)pyrene Benzopyrenes - pharmacology DNA - biosynthesis DNA - isolation & purification Hydroxyurea - pharmacology Lung - drug effects Lung - metabolism Male Rats Thymidine - metabolism
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Summary:	The authors have investigated the feasibility of utilizing a perfused rat lung model to: (1) determine whether DNA synthesis can be measured ex vivo by ( super(3)H)-thymidine incorporation, (2) determine the response of DNA synthesis to hydroxyurea with the eventual aim of characterizing chemically-induced DNA damage by measuring unscheduled DNA synthesis, and (3) to examine the effect of in vivo) pretreatment of the known pneumotoxic compound benzo(a)pyrene on DNA synthesis in the rat lung.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0007-4861 1432-0800
DOI:	10.1007/bf01608565