Antimicrobial Susceptibility Profile of Contemporary Clinical Strains of Stenotrophomonas maltophilia Isolates: Can Moxifloxacin Activity Be Predicted by Levofloxacin MIC Results?

The susceptibility profile of 763 Stenotrophomonas maltophilia isolates was evaluated against 16 antimicrobials by the CLSI reference broth microdilution method. Minocycline (MIC 90 , 1 μg/ml; 100.0% susceptible) was the most active compound, followed by doxycycline (MIC 90 , 4 μg/ml; 99.6% suscepti...

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Bibliographic Details
Published in:	Journal of chemotherapy (Florence) Vol. 20; no. 1; pp. 38 - 42
Main Authors:	Gales, A.C., Jones, R.N., Sader, H.S.
Format:	Journal Article
Language:	English
Published:	Firenze Taylor & Francis 01-02-2008 EIFT
Subjects:	Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Aza Compounds - pharmacology Biological and medical sciences Fluoroquinolones Humans in vitro activity In Vitro Techniques Levofloxacin Medical sciences Microbial Sensitivity Tests moxifloxacin Ofloxacin - pharmacology Pharmacology. Drug treatments Predictive Value of Tests Quinolines - pharmacology SENTRY Program Stenotrophomonas maltophilia Stenotrophomonas maltophilia - drug effects Stenotrophomonas maltophilia - isolation & purification Pseudomonadales Stenotrophomonas maltophilia Levofloxacin SENTRY Program Program Drug susceptibility test Moxifloxacin in vitro activity In vitro Biological activity Strain Fluoroquinolone derivatives Sensitivity resistance Minimum inhibitory concentration Bacteria Pseudomonadaceae Isolate fluoroquinolones Antibacterial agent Predictive factor Quinolone derivatives
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Summary:	The susceptibility profile of 763 Stenotrophomonas maltophilia isolates was evaluated against 16 antimicrobials by the CLSI reference broth microdilution method. Minocycline (MIC 90 , 1 μg/ml; 100.0% susceptible) was the most active compound, followed by doxycycline (MIC 90 , 4 μg/ml; 99.6% susceptible), trimethoprim/sulfamethoxazole (MIC 90 , 1 μg/ml; 97.8% susceptible), and tigecycline (MIC 90 , 2 μg/ml). An excellent correlation between levofloxacin (MIC 90 , 4 μg/ml; 86.5% susceptible by published breakpoint criteria) and moxifloxacin (MIC 90 , 2 μg/ml) MIC results was observed indicating that moxifloxacin could be further evaluated as a therapeutic option for S. maltophilia infections.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1120-009X 1973-9478
DOI:	10.1179/joc.2008.20.1.38