Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar rats

• Published in: The Journal of surgical research Vol. 120; no. 2; pp. 189 - 194
• Main Authors: Hodde, Jason P., Suckow, Mark A., Wolter, William R., Hiles, Michael C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-08-2004; Elsevier
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - physiopathology; Adenocarcinoma - secondary; Adenocarcinoma - surgery; angiogenesis; Animals; Biocompatible Materials; Biological and medical sciences; biomaterial; Cell Division; Collagen; General aspects; graft; Humans; Intestinal Mucosa - physiopathology; Intestine, Small - physiopathology; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Male; Medical sciences; metastasis; Neoplasm Recurrence, Local - pathology; Neoplasm Transplantation; Polytetrafluoroethylene; prostate cancer; Prostatic Neoplasms - pathology; Prostatic Neoplasms - physiopathology; Prostatic Neoplasms - surgery; Rats; Rats, Wistar; prostate cancer; graft; biomaterial; metastasis; angiogenesis; Rat; Rodentia; Malignant tumor; Small intestine; Medicine; Vertebrata; Mammalia; Treatment; Tumor growth; Animal; Surgery; Submucosa
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/j.jss.2003.10.022

Site-specific remodeling and angiogenesis are two observations associated with the use of small intestinal submucosa (SIS) as a tissue repair graft. Its angiogenic capacity has raised questions concerning its effect on tumor growth and metastasis in clinical tumor resection cases. The effect of SIS on the ability of neoplastic (prostate adenocarcinoma) cells to establish, grow, and metastasize was examined in Lobund-Wistar (L-W) rats.
In one study, SIS, expanded polytetrafluoroethylene (ePTFE), or human cadaveric dermis was placed in a subcutaneous pocket on the flank of L-W rats and immediately inoculated with PA-III cell suspension. Tumors were allowed to establish and metastasize for 5 weeks prior to sacrifice. Rate of tumor growth, tumor weight, and frequency of lung metastases were assessed. In a second study, SIS was placed in a resected tumor bed and tumors were allowed to recur. Rate of tumor growth, tumor weight, and frequency of lung metastases were assessed after 3 weeks.
ePTFE hastened the rate of formation of palpable tumors compared to controls and other materials; cadaveric dermis and SIS did not. No differences between materials were noted in final tumor weight nor in the frequency of metastasis to the lungs. Following surgical tumor resection, residual tumor cells led to recurrence of same-site tumors in all animals, but in the defects augmented with SIS, the tumors were significantly smaller than those which regrew in the resected, unaugmented group.
This study demonstrates that SIS does not enhance tumor establishment, growth, or metastasis in
de novo tumors. Furthermore, SIS appears to reduce the rate of tumor growth, but not metastasis, when applied in direct contact with a residual tumor bed in a rat model of prostate-related tumors.