Advanced Analytical Approach Based on Combination of FT-IR and Chemometrics for Quality Control of Pharmaceutical Preparations

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 6; p. 763
• Main Authors: Foschi, Martina, Marziale, Mariagrazia, Biancolillo, Alessandra
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18-06-2022; MDPI
• Subjects: Antibiotics; ATR-FTIR; Chromatography; classification; Design of experiments; discriminant analysis; Drugs; expired drugs; Feasibility studies; Humidity; Investigations; pharmaceutical drug authentication; Pharmaceutical industry; Quality control; Spectrum analysis; SPORT-LDA; United States > US
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph15060763

Background: The present work represents a feasibility study for the realization of an analytical method finalized to the detection of expired antibiotic tablets. The work focuses on a specific antibiotic drug and represents the preliminary study upstream of a larger-scale work. Methods: attenuated Total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) spectra coupled with sequential preprocessing through an orthogonalization (SPORT) chemometric approach were used to discriminate between expired and compliant tablets. Conclusions: The highest predictive accuracy (93.3% of correct classification rate in external validation, corresponding to 1 misclassified test sample over 15) was achieved by analyzing intact tablets. This represents an excellent result because it gives indications regarding the possibility of determining, in a completely non-destructive way, the presence of expired drugs.