THE FUNDAMENTAL STUDY ON THE MECHANISM OF THE CALCULI FORMATION (I)

• Published in: Kurume medical journal Vol. 5; no. 1; pp. 1 - 5
• Main Author: OGURA, RYOHEI
• Format: Journal Article
• Language: English
• Published: Kurume University School of Medicine 1958
• ISSN: 0023-5679; 1881-2090
• DOI: 10.2739/kurumemedj.5.1

It is important that the fundamental study must be done to make clear the mechanism of the calculi formation in the living body. Schade (1) observed the precipitation in the test tube by adding the calcium chloride on blood plasma, CaHPO4·2H2O, CaC2O4·2H2O, and CaCO3, while stirring. Observing of precipitation from crystalloid mixture, the crystal formation occurred when CaCl2-solution was dropped gently in the mixture of Na2HPO4 and KH2PO4. The similar phenomenon is considered that urine is dropped into vesiculi gently from ureter of a long lying pafient in bed. Mori (2) observed particularly the case of coexistence of colloid substance and chondroitin sulfuric acid. Miyamoto (3) mentioned the Pringsheim's phenomenon, and observed that the phase for the precipitation to appear was determined by concentration, and when the concentration reached to equillibrium, a semipermeable membrane was formed between the solutions. Furthermore, the crystal form in the colloid was observed (4). In the former report of our laboratory (5), it was demonstrated that, when the Ca3(PO4)2- acetic acid solution was mixed quickly with aqueous solution of ammonia, the precipitate did not coagulate, but when the solution was laid on top of aqueous solution of ammonia, precipitate could be taken out as the discoid coagulation.Generally, sulphuric calcium (gypsum, CaSO4·2H2O) shows a coagulatic phenomenon, and when it is heated to about 120°C, it forms a plaster of Paris (CaSO4·1/2H2O). When water is added to CaSO4·1/2H2O, it becomes hard as taking in water to molecule. Gypsum has a crystal water (2H2O) which arranges at metal-atom and has a close relation with hardness. It is interesting to know that CaSO4·2H2O is isomorphism with CaHPO4·2H2O in crystal form and they are almost equal in lattice constant as follows.a b c βCaSO4·2H2O 10.47KX 15.15 6.51 151.33’CaHPO4·2H2O 10.47 15.15 6.37 150.08’In this report, the explanation of agglutination in calcium phosphate was studied in view of the crystal water.