Plasma Concentrations, Pharmacokinetics and Urinary Excretion of Gatifloxacin after Single Intravenous Injection in Buffalo Calves

• Published in: Veterinary research communications Vol. 31; no. 8; pp. 1013 - 1020
• Main Authors: Raipuria, M, Dumka, V. K, Sandhu, H. S
• Format: Journal Article
• Language: English
• Published: Netherlands Dordrecht : Springer Netherlands 01-11-2007; Springer Nature B.V
• Subjects: animal diseases; animal pathogens; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - urine; Area Under Curve; bacterial infections; blood plasma; Body weight; buffaloes; Buffaloes - blood; Buffaloes - metabolism; Buffaloes - urine; dosage; drug evaluation; drug therapy; Excretion; Fluoroquinolones - administration & dosage; Fluoroquinolones - blood; Fluoroquinolones - pharmacokinetics; Fluoroquinolones - urine; Gatifloxacin; Half-Life; in vivo studies; Injection; Injections, Intravenous - veterinary; Intravenous administration; intravenous injection; Male; minimum inhibitory concentration; Pharmacokinetics; Plasma; quinolones; urine; young animals
• ISSN: 0165-7380; 1573-7446
• DOI: 10.1007/s11259-007-3343-7

The pharmacokinetics and urinary excretion of gatifloxacin were investigated after a single intravenous injection of 4 mg/kg body weight in buffalo calves. The therapeutic plasma drug concentration was maintained for up to 12 h. Gatifloxacin rapidly distributed from blood to tissue compartments, which was evident from the high values of the distribution rate constant, α₁ (11.1 ± 1.06 h-¹) and the rate constant of transfer of drug from central to peripheral compartment, k ₁₂ (6.29 ± 0.46 h-¹). The area under the plasma drug concentration-time curve and apparent volume of distribution were 17.1 ± 0.63 (μg.h)/ml and 3.56 ± 0.95 L/kg, respectively. The elimination half-life (t ₁/₂ β), total body clearance (ClB) and the ratio of drug present in tissues and plasma (T/P) were 10.4 ± 2.47 h, 235.1 ± 8.47 ml/(kg.h) and 10.1 ± 2.25, respectively. About 19.7% of the administered drug was excreted in urine within 24 h. A satisfactory intravenous dosage regimen for gatifloxacin in buffalo calves would be 5.3 mg/kg at 24 h intervals.