Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

• Published in: Translational vision science & technology Vol. 4; no. 1; p. 2
• Main Authors: van Zeeburg, Elsbeth J T, Braaf, Boy, Cereda, Matteo G, van Meurs, Jan C, de Boer, Johannes F
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01-01-2015
• Subjects: RPE-choroid graft; phase-resolved doppler OCT; SD-OCT
• ISSN: 2164-2591; 2164-2591
• DOI: 10.1167/tvst.4.1.2

We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT).
Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively.
The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage.
The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography.
The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies.